Daniel Swan

Daniel has a background in molecular developmental biology as both a PhD student (Imperial College, London) and a postdoc (Edinburgh University). mugshot_small

His first bioinformatics position was at The Genome Centre at Barts and The London Queen Mary’s School of Medicine and Dentistry in 2001 where he was largely focused on supporting clinical genomic investigations into complex human conditions such as obesity and diabetes.

In 2003 he moved to NERC Environmental Bioinformatics Centre (formerly the Enironmental Genomics Thematic Data Centre or EGTDC) supporting environmental genomics and post-genomic investigations, as well as developing the bioinformatics focused Linux distribution known as Bio-Linux.

In 2005 he took up his current position at Newcastle University to set up the Bioinformatics Support Unit.  His primary focus is genomics and transcriptomics/microarray analysis but also works on neuroinformatics projects as well as systems and synthetic biology.

Publications:

Ince RA, Petersen RS, Swan DC, Panzeri S. (2009) Python for information theoretic analysis of neural data. Front Neuroinformatics. 3: 4. Pubmed

Mark Carlile, Daniel Swan, Kelly Jackson, Keziah Preston-Fayers, Benoit Ballester, Paul Flicek and Andreas Werner (2009) Strand selective generation of endo-siRNAs from the Na/phosphate transporter gene Slc34a1 in murine tissues Nucleic Acids Research, February 23, doi:10.1093/nar/gkp088 Pubmed

M Hong, K R Ryan, P D Arkwright, A R Gennery, C Costigan, M Dominguez, D W Denning, V McConnell, A J Cant, M Abinun, G P Spickett, D C Swan, C S Gillespie, D A Young, D Lilic (2009) Pattern recognition receptor expression is not impaired in patients with chronic mucocutanous candidiasis with or without autoimmune polyendocrinopathy candidiasis ectodermal dystrophy. Clinical and experimental immunology (22 January) Pubmed

Werner A, Carlile M, Swan D. (2009) What do natural antisense transcripts regulate? RNA Biol. 2;6(1) Pubmed

Jackson KA, Valentine RA, McKay JA, Swan DC, Mathers JC, Ford D. (2008) Analysis of differential gene-regulatory responses to zinc in human intestinal and placental cell lines. Br J Nutr. : 1-10. Pubmed

Greenall A, Lei G, Swan DC, James K, Wang L, Peters H, Wipat A, Wilkinson DJ, Lydall D. (2008) A genome wide analysis of the response to uncapped telomeres in budding yeast reveals a novel role for the NAD+ biosynthetic gene BNA2 in chromosome end protection. Genome Biol. 9: R146. Pubmed

Waterhouse JC, Swan DC, Russell RR. (2007) Comparative genome hybridization of Streptococcus mutans strains. Oral Microbiol Immunol. 22: 103-110. PubMed

Field D, Tiwari B, Booth T, Houten S, Swan D, Bertrand N, Thurston M. (2006) Open software for biologists: from famine to feast. Nat Biotechnol. 24: 801-803. Pubmed

Allotey RA, Mohan V, McDermott MF, Deepa R, Premalatha G, Hassan Z, Cassell PG, North BV, Vaxillaire M, Mein CA, Swan DC, O’Grady E, Ramachandran A, Snehalatha C, Sinnot PJ, Hemmatpour SK, Froguel P, and Hitman GA. The EIF2AK3 gene region and type I diabetes in subjects from South India. Genes Immun 2004 Dec; 5(8) 648-52. doi:10.1038/sj.gene.6364139 pmid:15483661. PubMed

Aganna E, Martinon F, Hawkins PN, Ross JB, Swan DC, Booth DR, Lachmann HJ, Bybee A, Gaudet R, Woo P, Feighery C, Cotter FE, Thome M, Hitman GA, Tschopp J, and McDermott MF. Association of mutations in the NALP3/CIAS1/PYPAF1 gene with a broad phenotype including recurrent fever, cold sensitivity, sensorineural deafness, and AA amyloidosis. Arthritis Rheum 2002 Sep; 46(9) 2445-52. doi:10.1002/art.10509 pmid:12355493. PubMed

Korbonits M, Gueorguiev M, O’Grady E, Lecoeur C, Swan DC, Mein CA, Weill J, Grossman AB, and Froguel P. A variation in the ghrelin gene increases weight and decreases insulin secretion in tall, obese children. J Clin Endocrinol Metab 2002 Aug; 87(8) 4005-8. pmid:12161552. PubMed

Merry CL, Bullock SL, Swan DC, Backen AC, Lyon M, Beddington RS, Wilson VA, and Gallagher JT. The molecular phenotype of heparan sulfate in the Hs2st-/- mutant mouse. J Biol Chem 2001 Sep 21; 276(38) 35429-34. doi:10.1074/jbc.M100379200 pmid:11457822. PubMed

Episkopou V, Arkell R, Timmons PM, Walsh JJ, Andrew RL, and Swan D. Induction of the mammalian node requires Arkadia function in the extraembryonic lineages. Nature 2001 Apr 12; 410(6830) 825-30. doi:10.1038/35071095 pmid:11298452. PubMed